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概要
Janus Associated Kinase (JAK) Inhibitor I is a pyridine-containing tetracycle that disrupts JAK activity by interacting with the ATP binding domain. This inhibitor inhibits mouse JAK3 with Ki = 5 nM, JAK family members TYK2 and JAK2 with IC50 = 1 nM, and mouse JAK1 with IC50 = 15 nM, while showing weaker inhibition of other kinases (Thompson et al.).
REPROGRAMMING
· Inhibits the generation of mouse induced pluripotent stem cells (Efe et al.; Kim et al.).
IMMUNOLOGY
· Inhibits anti-viral response associated with JAK/STAT pathway activation (Xu et al.).
REPROGRAMMING
· Inhibits the generation of mouse induced pluripotent stem cells (Efe et al.; Kim et al.).
IMMUNOLOGY
· Inhibits anti-viral response associated with JAK/STAT pathway activation (Xu et al.).
技术资料
| Document Type | 产品名称 | Catalog # | Lot # | 语言 |
|---|---|---|---|---|
| Product Information Sheet | JAK Inhibitor I | 74022, 74024 | All | English |
| Safety Data Sheet | JAK Inhibitor I | 74022, 74024 | All | English |
