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概要
Indomethacin is a non-steroidal, anti-inflammatory agent that inhibits cyclooxygenase (COX) activity, thereby blocking the production of prostaglandins (Vane et al.). Indomethacin inhibits both COX-1 and COX-2 (IC50 = 0.08 and 0.96 µM for recombinant human COX-1 and COX-2, respectively; Kurumbail et al.).
DIFFERENTIATION
· Activates peroxisome proliferator-activated receptor-γ (PPARγ), a ligand-activated transcription factor known to play a pivotal role in adipogenesis (Lehmann et al.).
· Inhibits chondrogenic differentiation in ATDC5 cells and bone marrow stem cells (Caron et al.).
CANCER RESEARCH
· Inhibits growth of mouse mammary tumors (Fulton).
· Induces apoptosis in prostate and gastric cancer cells (Chiou et al.; Liu et al.).
DIFFERENTIATION
· Activates peroxisome proliferator-activated receptor-γ (PPARγ), a ligand-activated transcription factor known to play a pivotal role in adipogenesis (Lehmann et al.).
· Inhibits chondrogenic differentiation in ATDC5 cells and bone marrow stem cells (Caron et al.).
CANCER RESEARCH
· Inhibits growth of mouse mammary tumors (Fulton).
· Induces apoptosis in prostate and gastric cancer cells (Chiou et al.; Liu et al.).
技术资料
| Document Type | 产品名称 | Catalog # | Lot # | 语言 |
|---|---|---|---|---|
| Product Information Sheet 1 | Indomethacin | 73942 | All | English |
| Product Information Sheet 2 | Indomethacin | 73942 | All | English |
| Safety Data Sheet | Indomethacin | 73942 | All | English |
