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概要
Bafilomycin A1 is a macrolide antibiotic drug and autophagy inhibitor. It prevents the acidification of autophagosomes via the inhibition of vacuolar H+-ATPase (V-ATPase; Klionsky et al.).
MAINTENANCE AND SELF-RENEWAL
· Inhibits the proteolytic degradation associated with autophagy in human mesenchymal stem cells (Oliver et al.).
CANCER RESEARCH
· At low concentrations, it inhibits autophagy and promotes apoptotic cell death in pediatric B cell acute lymphoblastic leukemia (B-ALL) cells (Yuan et al.).
MAINTENANCE AND SELF-RENEWAL
· Inhibits the proteolytic degradation associated with autophagy in human mesenchymal stem cells (Oliver et al.).
CANCER RESEARCH
· At low concentrations, it inhibits autophagy and promotes apoptotic cell death in pediatric B cell acute lymphoblastic leukemia (B-ALL) cells (Yuan et al.).
技术资料
| Document Type | 产品名称 | Catalog # | Lot # | 语言 |
|---|---|---|---|---|
| Product Information Sheet | Bafilomycin A1 | 74242 | All | English |
| Safety Data Sheet | Bafilomycin A1 | 74242 | All | English |
