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概要
BMS 493 is an inverse agonist of the pan-retinoic acid receptors (RARs). RARs are ligand-dependent transcription factors that regulate gene networks that control cell growth, differentiation, survival, and death (Germain et al.). BMS 493 has been shown to increase nuclear receptor co-repressor (NCoR) interaction with RARs (Germain et al.; Rinkevich et al.).
DIFFERENTIATION
· Affects development of bronchial tubule formation in mice (Chazaud et al.).
· Inhibits activation of immature dendritic cells (Geissmann et al.).
CANCER RESEARCH
· Inhibits differentiation of leukemic blasts (Kamashev et al.).
DIFFERENTIATION
· Affects development of bronchial tubule formation in mice (Chazaud et al.).
· Inhibits activation of immature dendritic cells (Geissmann et al.).
CANCER RESEARCH
· Inhibits differentiation of leukemic blasts (Kamashev et al.).
技术资料
| Document Type | 产品名称 | Catalog # | Lot # | 语言 |
|---|---|---|---|---|
| Product Information Sheet | BMS 493 | 73972, 73974 | All | English |
| Safety Data Sheet | BMS 493 | 73972, 73974 | All | English |
