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概要
SAHA (suberoylanilide hydroxamic acid) is a potent inhibitor of class I and class II histone deacetylases (HDACs). This compound inhibits the activities of HDAC1 and HDAC3 (IC50 = 10 nM and 20 nM, respectively; Richon et al.). SAHA exhibits antiproliferative properties and can cause cell cycle arrest at G1 (Marks & Breslow).
REPROGRAMMING
· Improves reprogramming efficiency from human and mouse somatic to induced pluripotent stem cells (Huangfu et al.).
CANCER RESEARCH
· Downregulates homologous recombination and leads to apoptosis in ovarian cancer cells when used in combination with olaparib (Konstantinopoulos et al.).
· SAHA downregulates Nanog expression, which leads to proliferation inhibition in head and neck cancer stem cells (Kumar et al.).
REPROGRAMMING
· Improves reprogramming efficiency from human and mouse somatic to induced pluripotent stem cells (Huangfu et al.).
CANCER RESEARCH
· Downregulates homologous recombination and leads to apoptosis in ovarian cancer cells when used in combination with olaparib (Konstantinopoulos et al.).
· SAHA downregulates Nanog expression, which leads to proliferation inhibition in head and neck cancer stem cells (Kumar et al.).
技术资料
| Document Type | 产品名称 | Catalog # | Lot # | 语言 |
|---|---|---|---|---|
| Product Information Sheet | SAHA | 73902, 73904 | All | English |
| Safety Data Sheet | SAHA | 73902, 73904 | All | English |
