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Pyrintegrin

Integrin and tyrosine kinase activator; Activates Integrin, FGFR, IGFR and HER2

概要
技术资料
数据及文献

概要

Pyrintegrin is a 2,4-disubstituted pyrimidine that  induces the activation of β1 integrin and multiple growth factor receptors, including FGFR1, IGFR1, EGFR1, and HER2 (Xu et al.).

MAINTENANCE AND SELF-RENEWAL
· Enhances integrin-dependent attachment and survival of human embryonic stem (ES) cells following trypsin-mediated single-cell dissociation (Xu et al.).

技术资料

Document Type 产品名称 Catalog # Lot # 语言
Product Information Sheet Pyrintegrin 72842, 72844 All English
Safety Data Sheet Pyrintegrin 72842, 72844 All English

数据及文献

Publications (1)

Proceedings of the National Academy of Sciences of the United States of America 2010 MAY Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Xu Y et al.

Abstract

Using a high-throughput chemical screen, we identified two small molecules that enhance the survival of human embryonic stem cells (hESCs). By characterizing their mechanisms of action, we discovered an essential role of E-cadherin signaling for ESC survival. Specifically, we showed that the primary cause of hESC death following enzymatic dissociation comes from an irreparable disruption of E-cadherin signaling, which then leads to a fatal perturbation of integrin signaling. Furthermore, we found that stability of E-cadherin and the resulting survival of ESCs were controlled by specific growth factor signaling. Finally, we generated mESC-like hESCs by culturing them in mESC conditions. And these converted hESCs rely more on E-cadherin signaling and significantly less on integrin signaling. Our data suggest that differential usage of cell adhesion systems by ESCs to maintain self-renewal may explain their profound differences in terms of morphology, growth factor requirement, and sensitivity to enzymatic cell dissociation.
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