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概要
Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a reversible, highly potent activator of protein kinase C (PKC), including Group A and Group B isoforms (Blumberg). PMA activates PKC isoforms through the binding of the C1 domain (Hurley et al.). PMA can also activate certain mitogen-activated protein (MAP) kinase pathways through PKC (Adams & Parker).
DIFFERENTIATION
· Stimulates cardiac differentiation of mesenchymal stem cells (Seo et al.).
· Promotes hematopoietic differentiation (Clemens et al.).
IMMUNOLOGY
· Stimulates differentiation of IL-15-stimulated lamina propria CD4+ T cells into CXCR5+CD4+ cells when used together with ionomicin (Sarra et al.).
CANCER RESEARCH
· In combination with AS101, it shows anti-leukemic activity and stimulates human leukemia cell lines to differentiate into macrophage-like cells (Glesne & Huberman; Hayun et al.).
DIFFERENTIATION
· Stimulates cardiac differentiation of mesenchymal stem cells (Seo et al.).
· Promotes hematopoietic differentiation (Clemens et al.).
IMMUNOLOGY
· Stimulates differentiation of IL-15-stimulated lamina propria CD4+ T cells into CXCR5+CD4+ cells when used together with ionomicin (Sarra et al.).
CANCER RESEARCH
· In combination with AS101, it shows anti-leukemic activity and stimulates human leukemia cell lines to differentiate into macrophage-like cells (Glesne & Huberman; Hayun et al.).
技术资料
| Document Type | 产品名称 | Catalog # | Lot # | 语言 |
|---|---|---|---|---|
| Product Information Sheet 1 | Phorbol 12-myristate 13-acetate | 74042, 74044 | BX24679 to BX37212 | English |
| Product Information Sheet 2 | Phorbol 12-myristate 13-acetate | 74042, 74044 | BX37576 or higher | English |
| Product Information Sheet 3 | Phorbol 12-myristate 13-acetate | 74042, 74044 | BX24678 or lower | English |
| Safety Data Sheet | Phorbol 12-myristate 13-acetate | 74042, 74044 | All | English |
