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概要
Interleukin 22 (IL-22) is a class 2 α-helical cytokine that signals through the class 2 cytokine receptor and activates the JAK/STAT pathway. IL-22 is secreted by Th1, Th2, Tc22, and γδ T cells, dendritic, mast and NK cells. It stimulates expression of antimicrobial peptides from epithelial cells, thus hindering bacterial infections. Depending on the interactions with other cytokines, IL-22 can either promote inflammation or prevent tissue destruction by regulating host defense and tissue homeostasis at barrier surfaces (Sonnenberg et al.).
技术资料
| Document Type | 产品名称 | Catalog # | Lot # | 语言 |
|---|---|---|---|---|
| Product Information Sheet | Human Recombinant IL-22 | 78038, 78038.1 | All | English |
| Safety Data Sheet | Human Recombinant IL-22 | 78038, 78038.1 | All | English |
数据及文献
Data
(A) The biological activity of Human Recombinant IL-22 was tested by its ability to produce IL-10 in COLO 205 cells. IL-10 secretion was
measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell
proliferation is at 50% of maximum. The EC50 in the above example is less than 1 ng/mL.
(B) 2 μg of Human Recombinant IL-22 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized
by Coomassie Blue staining. Human Recombinant IL-22 has a predicted molecular mass of 16.9 kDa.
