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概要
Growth differentiation factor 11 (GDF-11) is a member of transforming growth factor beta (TGF-β) family. It binds to the TGF-β receptors ALK4, ALK5, and ALK7 and activates the SMAD signaling pathway (Ho et al.). GDF-11 regulates the development of the olfactory system, retina, and pancreas, as well as anterior/posterior patterning of the axial skeleton (Lee & Lee). GDF-11 is an endocrine factor expressed in skeletal muscle, brain, and dental pulp (Kondás et al.). Studies in mice showed that GDF-11 regulates muscle and cardiac aging, and stimulates neurogenesis by remodeling blood vessels (Katsimpardi et al.; Loffredo et al.; Sinha et al.).
技术资料
| Document Type | 产品名称 | Catalog # | Lot # | 语言 |
|---|---|---|---|---|
| Product Information Sheet 1 | Human Recombinant GDF-11 | 78110, 78110.1 | All | English |
| Product Information Sheet 2 | Human Recombinant GDF-11 | 78110, 78110.1 | All | English |
| Safety Data Sheet | Human Recombinant GDF-11 | 78110, 78110.1 | All | English |
数据及文献
Data
(A) The biological activity of Human Recombinant GDF-11 was tested by its ability to inhibit alkaline phosphatase production in ATDC-5 cells. Inhibition of alkaline phosphatase production was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which alkaline phosphatase activity is at 50% of maximum. The EC50 in the above example is 2.63 ng/mL. (B) 1 μg of Human Recombinant GDF-11 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.
