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概要
Follistatin, a glycosylated monomeric protein, is a modulator of transforming growth factor beta (TGF-β) superfamily signaling. It binds to and inhibits the function of activin, myostatin, growth differentiation factors, and bone morphogenetic proteins (BMP) (Hansen & Plomgaard). Follistatin inhibits mesoderm induction, suppresses synthesis and secretion of pituitary follicle-stimulating hormone, regulates liver regeneration, and causes infertility (Guo et al.; Iemura et al.). Follistatin exhibits anti-inflammatory effects, and it could be used as a biomarker in cancer (Hansen & Plomgaard).
技术资料
| Document Type | 产品名称 | Catalog # | Lot # | 语言 |
|---|---|---|---|---|
| Product Information Sheet | Human Recombinant Follistatin | 78109, 78109.1 | All | English |
| Safety Data Sheet | Human Recombinant Follistatin | 78109, 78109.1 | All | English |
数据及文献
Data
(A) The biological activity of Human Recombinant Follistatin was tested by neutralization of human activin A induced cytotoxicity of MPC- 11 cells. Cell viability was measured after 66 hours using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell viability is at 50% of maximum. The EC50 in the above example is 0.04 μg/mL. (B) 1 μg of Human Recombinant Follistatin was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.
