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概要
Fibroblast growth factor 6 (FGF-6) is a heparin-binding member of the FGF family, regulators of cell proliferation, differentiation, and function. FGF-6 binds and signals through the FGF receptors 1c, 2c, and 4 (Ornitz et al.). FGF-6 is a potent mitogen for fibroblasts, vascular endothelial cells, and prostate carcinoma cells (Asada et al.; Pizette et al.; Ropiquet et al.). FGF-6 is primarily expressed in epithelial and mesenchymal cell lineages. During development, FGF-6 is expressed in skeletal muscle, consistent with its role in muscle differentiation and regeneration (Floss et al.). FGF-6 has also been shown to promote chondrogenesis in embryonic somites in conjunction with transforming growth factor beta 2 (TGF-β2; Grass et al.).
技术资料
| Document Type | 产品名称 | Catalog # | Lot # | 语言 |
|---|---|---|---|---|
| Product Information Sheet | Human Recombinant FGF-6 | 78184, 78184.1 | All | English |
| Safety Data Sheet | Human Recombinant FGF-6 | 78184, 78184.1 | All | English |
数据及文献
Data
(A) The biological activity of Human Recombinant FGF-6 was tested by its ability to promote proliferation of NR6R-3T3 cells in the presence of 1 μg heparin. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is 0.00442 ng/mL. (B) 1 μg of Human Recombinant FGF-6 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant FGF-6 has a predicted molecular mass of 18.9 kDa.
