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概要
Bone morphogenetic protein receptor type 1A (BMPR-1A) is a type I receptor of the BMP receptor family of transmembrane serine/threonine kinases (Abe; Fischerauer et al.); it is also known as ALK3. BMPR-1A is a receptor for BMP-2, BMP-4, GDF-5, and GDF-6. Binding of BMPs to receptor complexes results in phosphorylation of intracellular SMADs, which go on to regulate transcription (Pan et al.). BMP regulation plays a role in proliferation, differentiation, migration, and apoptosis of endothelial and vascular smooth muscle cells (Abe). BMPR-1A deficiency is lethal during gastrulation (Mishina et al.). BMPR-1A is important in chondrogenesis and osteogenesis, along with BMPR-1B (Fischerauer et al.; Jing et al.). This protein contains a C-terminus linker (IEGRMD) to an Fc tag (Human IgG1).
技术资料
| Document Type | 产品名称 | Catalog # | Lot # | 语言 |
|---|---|---|---|---|
| Product Information Sheet | Human Recombinant BMPR-1A Fc | 78212, 78212.1, 78212.2, 78212.3 | All | English |
| Safety Data Sheet | Human Recombinant BMPR-1A Fc | 78212, 78212.1, 78212.2, 78212.3 | All | English |
数据及文献
Data
The biological activity of Human Recombinant BMPR-1A Fc was tested by its ability to inhibit BMP-4-induced alkaline phosphatase production in ATDC-5 cells. Inhibition of BMP-4-induced alkaline phosphatase production was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which inhibition of alkaline phosphatase production is at 50% of maximum. The EC50 in the above example is 61.5 ng/mL.
