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概要
Interleukin 22 (IL-22) is a class 2 α-helical cytokine that signals through the class 2 cytokine receptor and activates the JAK/STAT pathway. IL-22 is secreted by Th1, Th2, Tc22, and γδ T cells, dendritic, mast and NK cells. It stimulates expression of antimicrobial peptides from epithelial cells, thus hindering bacterial infections. Depending on the interactions with other cytokines, IL-22 can either promote inflammation or prevent tissue destruction by regulating host defense and tissue homeostasis at barrier surfaces (Sonnenberg et al.).
技术资料
| Document Type | 产品名称 | Catalog # | Lot # | 语言 |
|---|---|---|---|---|
| Product Information Sheet | Mouse Recombinant IL-22 | 78039, 78039.1 | All | English |
| Safety Data Sheet | Mouse Recombinant IL-22 | 78039, 78039.1 | All | English |
数据及文献
Data
(A) The biological activity of Mouse Recombinant IL-22 was tested by its ability to produce IL-10 in COLO 205 cells. IL-10 secretion was
measured after 4 days of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth
factor at which IL-10 production is at 50% of maximum. The EDC50 in the above example is 0.15 - 0.23 ng/mL.
(B) 1 μg of Mouse Recombinant L-22 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by
Coomassie Blue staining. Mouse Recombinant IL-22 has a predicted molecular mass of 16.8 kDa.
