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概要
Transforming growth factor (TGF) beta 2 is a member of the TGF-β superfamily and regulates diverse cellular phenotypes. Similar to TGF-β1 & -β3, TGF-β2 signals via serine-threonine kinase type I and II receptors and activates signal transduction via SMAD family proteins, regulating a variety of functions such as cell proliferation, differentiation, wound healing, apoptosis, and metabolism (de Caestecker; Massague; Zuniga et al.). TGF-β2 is important in many developmental processes; for example, mice with TGF-β2 deletions show defects in the development of cardiac, lung, craniofacial, limb, eye, ear, and urogenital systems (Dunker & Kreiglstein).
技术资料
| Document Type | 产品名称 | Catalog # | Lot # | 语言 |
|---|---|---|---|---|
| Product Information Sheet | Human Recombinant TGF-beta 2 | 78174, 78174.1 | All | English |
| Safety Data Sheet | Human Recombinant TGF-beta 2 | 78174, 78174.1 | All | English |
数据及文献
Data
(A) The biological activity of Human Recombinant TGF-beta 2 was tested by its ability to promote the proliferation of mouse HT-2 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 0.2 ng/mL. (B) 5 μg of Human Recombinant TGF-beta 2 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant TGF-beta 2 has a predicted molecular mass of 12.7 kDa.
