Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3_产品中心_北京砺达辰生物科技有限公司

抗体

Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3

Hamster (Armenian) monoclonal IgG2 antibody against mouse T Cell receptor gamma/delta

概要

技术资料

数据及文献

概要

The GL3 antibody reacts with the δ chain of the murine T cell receptor γ/δ (TCRγ/δ or TCR gamma/delta), a subtype of the TCR involved in the recognition of both peptide and lipid antigens. TCRγ/δ comprises a heterodimer (~ 80 kDa in humans) of disulfide-linked γ and δ subunits that associates with CD3 on the cell surface. It is a member of the immunoglobulin superfamily. TCRγ/δ is expressed on a subpopulation of T cells in the circulation but may be found on up to 50% of the T cells in epithelial cell-rich tissues. These cells have roles in oral and tumor-associated tolerance as well as autoimmune disease and have been described as a link between the adaptive and innate immune responses. Once activated, they secrete effector cytokines in a subtype- and context-specific manner. Most γ/δ T cells are CD4-/CD8-, though some express CD8. The GL3 antibody recognizes an epitope in the constant region of the δ chain and can reportedly activate TCRγ/δ+ cells.

技术资料

Document Type	产品名称	Catalog #	Lot #	语言
Product Information Sheet	Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3	60104	All	English
Product Information Sheet	Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3, Alexa Fluor® 488	60104AD, 60104AD.1	All	English
Product Information Sheet	Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3, APC	60104AZ, 60104AZ.1	All	English
Product Information Sheet	Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3, Biotin	60104BT, 60104BT.1, 60104BT.2	All	English
Product Information Sheet	Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3, FITC	60104FI, 60104FI.1	All	English
Product Information Sheet	Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3, PE	60104PE, 60104PE.1	All	English
Safety Data Sheet	Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3	60104	All	English
Safety Data Sheet	Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3, Alexa Fluor® 488	60104AD, 60104AD.1	All	English
Safety Data Sheet	Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3, APC	60104AZ, 60104AZ.1	All	English
Safety Data Sheet	Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3, Biotin	60104BT, 60104BT.1, 60104BT.2	All	English
Safety Data Sheet	Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3, FITC	60104FI, 60104FI.1	All	English
Safety Data Sheet	Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3, PE	60104PE, 60104PE.1	All	English

数据及文献

Data

Figure 1. Data for Unconjugated

(A) Flow cytometry analysis of C57BL/6 mouse lymph node cells labeled with Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3, followed by an anti-hamster (Armenian) IgG antibody, FITC and Anti-Mouse CD3e Antibody, Clone 145-2C11, APC (Catalog #60015AZ).

Figure 2. Data for Alexa Fluor® 488-Conjugated

(A) Flow cytometry analysis of C57BL/6 mouse lymph node cells labeled with Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3, Alexa Fluor® 488 and Anti-Mouse CD3e Antibody, Clone 145-2C11, APC (Catalog #60015AZ).

Figure 3. Data for APC-Conjugated

(A) Flow cytometry analysis of C57BL/6 mouse lymph node cells labeled with Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3, APC and Anti-Mouse CD3e Antibody, Clone 145-2C11, PE (Catalog #60015PE).

Figure 4. Data for Biotin-Conjugated

(A) Flow cytometry analysis of C57BL/6 mouse lymph node cells labeled with Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3, Biotin followed by streptavidin (SAV) APC and Anti-Mouse CD3e Antibody, Clone 145-2C11, PE (Catalog #60015PE).

Figure 5. Data for FITC-Conjugated

(A) Flow cytometry analysis of C57BL/6 mouse lymph node cells labeled with Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3, FITC and Anti-Mouse CD3e Antibody, Clone 145-2C11, APC (Catalog #60015AZ).

Figure 6. Data for PE-Conjugated

(A) Flow cytometry analysis of C57BL/6 mouse lymph node cells labeled with Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3, PE and Anti-Mouse CD3e Antibody, Clone 145-2C11, APC (Catalog #60015AZ).