Anti-Mouse IFN-gamma Antibody, Clone XMG1.2_产品中心_北京砺达辰生物科技有限公司

概要

The XMG1.2 antibody reacts with mouse interferon-gamma (IFN-γ), a glycosylated type II interferon comprising a homodimer of ~20 kDa subunits in its active form. IFN-γ is produced primarily by activated T lymphocytes and natural killer (NK) cells in response to antigens, including alloantigens, mitogens, and enterotoxins. IFN-γ binds with high affinity to the α subunit of the IFN-γ receptor, resulting in the ligand-induced assembly of a tetrameric α2β2 receptor complex capable of mediating the cellular response to the cytokine through activation of the JAK-STAT pathway. The IFN-γ receptor is expressed on the surface of all nucleated cells. IFN-γ has important functions in a wide range of biological processes, including macrophage activation, mediating the immune response to viruses and bacteria, and modulating cellular proliferation and apoptosis. The XMG1.2 antibody is suitable for detection of intracellular IFN-γ by methods such as flow cytometry, when paired with an appropriate secondary antibody. The XMG1.2 antibody is also widely used in various assays to neutralize the functional activity of IFN-γ.

技术资料

Document Type	产品名称	Catalog #	Lot #	语言
Product Information Sheet	Anti-Mouse IFN-gamma Antibody, Clone XMG1.2, APC	100-0277, 100-0278	All	English
Product Information Sheet	Anti-Mouse IFN-gamma Antibody, Clone XMG1.2, PE	100-0279, 100-0280	All	English
Product Information Sheet	Anti-Mouse IFN-gamma Antibody, Clone XMG1.2, FITC	100-0281, 100-0282	All	English
Product Information Sheet	Anti-Mouse IFN-gamma Antibody, Clone XMG1.2, Biotin	100-0283, 100-0284	All	English
Safety Data Sheet	Anti-Mouse IFN-gamma Antibody, Clone XMG1.2, APC	100-0277, 100-0278	All	English
Safety Data Sheet	Anti-Mouse IFN-gamma Antibody, Clone XMG1.2, PE	100-0279, 100-0280	All	English
Safety Data Sheet	Anti-Mouse IFN-gamma Antibody, Clone XMG1.2, FITC	100-0281, 100-0282	All	English
Safety Data Sheet	Anti-Mouse IFN-gamma Antibody, Clone XMG1.2, Biotin	100-0283, 100-0284	All	English

数据及文献

Data

Figure showing flow cytometry analysis of anti-mouse IFN-gamma antibody Clone XMG1.2, APC, and anti-mouse CD3e antibody, clone 145-2C11, PE.

Figure 1. Data for Anti-Mouse IFN-gamma Antibody, Clone XMG1.2, APC

Flow cytometry analysis of (A) unstimulated C57BL/6 mouse splenocytes labeled with Anti-Mouse IFN-gamma Antibody, Clone XMG1.2, APC, and anti-mouse CD3e antibody, clone 145-2C11, PE and (B) PMA/ionomycin-stimulated C57BL/6 mouse splenocytes labeled with Anti-Mouse IFN-gamma Antibody, Clone XMG1.2, APC, and anti-mouse CD3e antibody, clone 145-2C11, PE.

Figure showing flow cytometry analysis of anti-mouse IFN-gamma antibody Clone XMG1.2, Biotin.

Figure 2. Data for Anti-Mouse IFN-gamma Antibody, Clone XMG1.2, Biotin

Flow cytometry analysis of PMA/ionomycin-stimulated C57BL/6 mouse splenocytes labeled with Anti-Mouse IFN-γ Antibody, Clone XMG1.2, Biotin, followed by streptavidin (SAV) PE.

Figure showing flow cytometry analysis of anti-mouse IFN-gamma antibody, Clone XMG1.2, FITC.

Figure 3. Data for Anti-Mouse IFN-gamma Antibody, Clone XMG1.2, FITC

Flow cytometry analysis of PMA/ionomycin-stimulated C57BL/6 mouse splenocytes labeled with Anti-Mouse IFN-gamma Antibody, Clone XMG1.2, FITC.

Figure showing flow cytometry analysis of anti-mouse IFN-gamma antibody Clone XMG1.2, PE, and anti-mouse CD3e antibody, clone 145-2C11, APC.

Figure 4. Data for Anti-Mouse IFN-gamma Antibody, Clone XMG1.2, PE

Flow cytometry analysis of (A) unstimulated C57BL/6 mouse splenocytes labeled with Anti-Mouse IFN-gamma Antibody, Clone XMG1.2, PE, and anti-mouse CD3e antibody, clone 145-2C11, APC and (B) PMA/ionomycin-stimulated C57BL/6 mouse splenocytes labeled with Anti-Mouse IFN-gamma Antibody, Clone XMG1.2, PE, and anti-mouse CD3e antibody, clone 145-2C11, APC.