Anti-Mouse EPCR Antibody, Clone RMEPCR1560 (1560)_产品中心

概要

The RMEPCR1560 (1560) antibody reacts with the endothelial protein C receptor (EPCR or CD201), an ~25 kDa type I transmembrane glycoprotein expressed by endothelial cells, subsets of hematopoietic stem cells (HSCs) and dendritic cells, and several malignant cell lines. It is also found in a soluble form in plasma. EPCR exhibits homology with the MHC class 1/CD1 protein family. EPCR binds protein C and activated protein C, thus augmenting protein C activation by the thrombin-thrombomodulin complex and regulating blood coagulation and inflammation. EPCR protein expression has been detected on ~1.5% of mouse bone marrow cells. Purified EPCR+ cells are highly enriched for HSC activity, as evidenced by high in vivo repopulation activity. Moreover, EPCR expression is associated with the stem cell activity of bone marrow cell populations isolated using conventional markers, indicating the usefulness of EPCR as a single marker for the identification of mouse HSCs.

技术资料

Document Type	产品名称	Catalog #	Lot #	语言
Product Information Sheet	Anti-Mouse EPCR Antibody, Clone RMEPCR1560 (1560)	60038	All	English
Product Information Sheet	Anti-Mouse EPCR Antibody, Clone RMEPCR1560 (1560), Biotin	60038BT	All	English
Product Information Sheet	Anti-Mouse EPCR Antibody, Clone RMEPCR1560 (1560), FITC	60038FI, 60038FI.1	All	English
Product Information Sheet	Anti-Mouse EPCR Antibody, Clone RMEPCR1560 (1560), PE	60038PE, 60038PE.1	All	English
Safety Data Sheet	Anti-Mouse EPCR Antibody, Clone RMEPCR1560 (1560)	60038	All	English
Safety Data Sheet	Anti-Mouse EPCR Antibody, Clone RMEPCR1560 (1560), Biotin	60038BT	All	English
Safety Data Sheet	Anti-Mouse EPCR Antibody, Clone RMEPCR1560 (1560), FITC	60038FI, 60038FI.1	All	English
Safety Data Sheet	Anti-Mouse EPCR Antibody, Clone RMEPCR1560 (1560), PE	60038PE, 60038PE.1	All	English

数据及文献

Data

Figure 1. Data for Unconjugated

Flow cytometry analysis of HEK-293 mEPCR-transfected cells (filled histogram) or non-transfected HEK-293 cells (negative control; dashed line histogram), labeled with Anti-Mouse EPCR Antibody, Clone RMEPCR1560, followed by Goat Anti-Mouse IgG (H+L) Antibody, Polyclonal, FITC (Catalog #60138FI). Labeling of HEK-293 mEPCR-transfected cells with a rat IgG2b, kappa isotype control antibody, followed by Goat Anti-Mouse IgG (H+L) Antibody, Polyclonal, FITC is shown (solid line histogram).

Figure 2. Data for Biotin-Conjugated

Flow cytometry analysis of HEK-293 mEPCR-transfected cells (filled histogram) or non-transfected HEK-293 cells (negative control cells, dashed line histogram), labeled with Anti-Mouse EPCR Antibody, Clone RMEPCR1560, Biotin followed by streptavidin (SAV) APC. Labeling of HEK-293 mEPCR-transfected cells with a rat IgG2b, kappa isotype control antibody followed by SAV APC is shown (solid line histogram).

Figure 3. Data for FITC-Conjugated

Flow cytometry analysis of HEK-293 mEPCR-transfected cells (filled histogram) or non-transfected HEK-293 cells (negative control cells, dashed line histogram), labeled with Anti-Mouse EPCR Antibody, Clone RMEPCR1560 FITC. Labeling of HEK-293 mEPCR-transfected cells with a rat IgG2b, kappa FITC isotype control antibody is shown (solid line histogram).

Figure 4. Data for PE-Conjugated

Flow cytometry analysis of HEK-293 mEPCR-transfected cells (filled histogram) or non-transfected HEK-293 cells (negative control cells, dashed line histogram), labeled with Anti-Mouse EPCR Antibody, Clone RMEPCR1560, PE. Labeling of HEK-293 mEPCR-transfected cells with a rat IgG2b, kappa PE isotype control antibody is shown (solid line histogram).