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概要
The DECMA-1 antibody recognizes E-cadherin, a calcium-dependent transmembrane glycoprotein involved in cell-cell adhesion, bacterial pathogenesis, and tumor invasion. The extracellular region of E-cadherin is composed of multiple cadherin repeats that contain calcium-binding motifs. The cytoplasmic domain of E-cadherin is reported to interact with a range of intracellular proteins including erbin, ezrin, caspase-3, caspase-8, β-catenin, presenilin 1, and casein kinase II. E-cadherin is expressed in most epithelial cells and in erythroid cells. The E-cadherin antibody is often used as a neutralizing antibody to inhibit E-cadherin-mediated cell-cell interactions.
技术资料
| Document Type | 产品名称 | Catalog # | Lot # | 语言 |
|---|---|---|---|---|
| Product Information Sheet | Anti-Mouse E-Cadherin (CD324) Antibody, Clone DECMA-1 | 60157, 60157.1 | All | English |
| Safety Data Sheet | Anti-Mouse E-Cadherin (CD324) Antibody, Clone DECMA-1 | 60157, 60157.1 | All | English |
数据及文献
Data
(A) Primary human airway epithelial cells were expanded in a submerged culture with PneumaCult™-Ex Medium (Catalog #05008). The cells were labeled with Anti-Mouse E-Cadherin (CD324) Antibody, Clone DECMA-1, followed by a donkey anti-mouse IgG antibody, Alexa Fluor® 488, and counterstained with DAPI. (B) Flow cytometry analysis of MDCK epithelial cells labeled with Anti-Mouse E-Cadherin (CD324) Antibody, Clone DECMA-1, followed by an anti-rat IgG1 antibody, PE (filled histogram) or Rat IgG1, kappa Isotype Control Antibody, Clone RTK2071 (Catalog #60075), followed by an anti-rat IgG1 antibody, PE (dotted line histogram).
