Anti-Mouse CD267 (TACI) Antibody, Clone 8F10_产品中心_北京砺达辰生物科技有限公司

抗体

Anti-Mouse CD267 (TACI) Antibody, Clone 8F10

Rat monoclonal IgG2a antibody against mouse CD267 (TACI)

概要

技术资料

数据及文献

概要

The 8F10 antibody reacts with mouse CD267 (transmembrane activator and CAML interactor, or TACI), an ~30 kDa type III transmembrane protein of the TNF receptor superfamily that is expressed primarily on the surface of maturing subsets of splenic B cells, including transition type 2 (T2) and marginal zone (MZ) B cells, as well as on plasma cells and plasmablasts. Expression of CD267 is upregulated on B cells exposed to LPS both in vitro and in vivo. CD267 plays important roles in humoral immunity by regulating B cell survival, proliferation, and maturation through its interaction with the ligands APRIL and BAFF. Ligand binding stimulates activation of several transcription factors, including NF-kappa-B, and has been shown to induce either proliferation or apoptosis, suggesting a dual role in the regulation of B cells. CD267 also appears to have an essential function in immunoglobulin isotype switching and B cell differentiation in response to thymus-independent antigens.

技术资料

Document Type	产品名称	Catalog #	Lot #	语言
Product Information Sheet	Anti-Mouse CD267 (TACI) Antibody, Clone 8F10, APC	60116AZ, 60116AZ.1	All	English
Product Information Sheet	Anti-Mouse CD267 (TACI) Antibody, Clone 8F10, PE	60116PE, 60116PE.1	All	English
Safety Data Sheet	Anti-Mouse CD267 (TACI) Antibody, Clone 8F10, APC	60116AZ, 60116AZ.1	All	English
Safety Data Sheet	Anti-Mouse CD267 (TACI) Antibody, Clone 8F10, PE	60116PE, 60116PE.1	All	English

数据及文献

Data

Figure 1. Data for APC-Conjugated

(A) Flow cytometry analysis of immunized C57BL/6 mouse splenocytes labeled with Anti-Mouse CD267 (TACI) Antibody, Clone 8F10, APC and Anti-Mouse CD138 (Syndecan-1) Antibody, Clone 281-2, PE (Catalog #60035PE). (B) Flow cytometry analysis of immunized C57BL/6 mouse splenocytes labeled with a rat IgG2a, kappa isotype control antibody, APC and Anti-Mouse CD138 (Syndecan-1) Antibody, Clone 281-2, PE (Catalog #60035PE).

Figure 2. Data for PE-Conjugated

(A) Flow cytometry analysis of immunized C57BL/6 mouse splenocytes labeled with Anti-Mouse CD267 (TACI) Antibody, Clone 8F10, PE and Anti-Mouse CD138 (Syndecan-1) Antibody, Clone 281-2, APC (Catalog #60035AZ). (B) Flow cytometry analysis of immunized C57BL/6 mouse splenocytes labeled with a rat IgG2a, kappa isotype control antibody, PE and Anti-Mouse CD138 (Syndecan-1) Antibody, Clone 281-2, APC (Catalog #60035AZ).