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概要
The LG.3A10 antibody reacts with CD27, a 45 - 55 kDa member of the tumor necrosis factor receptor superfamily. CD27 is found on peripheral T cells, memory B cells, and NK cells and in mice has been found on most thymocytes, except CD46-CD8- precursors. CD27 and its ligand CD70 are involved in multiple aspects of T cell biology, including the costimulation and expansion of CD4+ and CD8+ T cells and differentiation to memory CD8+ T cells. CD27 interacts with TRAF family members, resulting in enhanced cellular proliferation and the induction of anti-apoptotic proteins. Additionally, CD27 plays important roles in T cell – B cell interactions and the maturation of effector T cells. The expansion of activated B cells and their differentiation to plasma cells is also reported to be enhanced by CD27.
技术资料
| Document Type | 产品名称 | Catalog # | Lot # | 语言 |
|---|---|---|---|---|
| Product Information Sheet | Anti-Mouse CD27 Antibody, Clone LG.3A10 | 60160 | All | English |
| Product Information Sheet | Anti-Mouse CD27 Antibody, Clone LG.3A10, PE | 60160PE, 60160PE.1 | All | English |
| Safety Data Sheet | Anti-Mouse CD27 Antibody, Clone LG.3A10 | 60160 | All | English |
| Safety Data Sheet | Anti-Mouse CD27 Antibody, Clone LG.3A10, PE | 60160PE, 60160PE.1 | All | English |
数据及文献
Data
Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Anti-Mouse CD27 Antibody, Clone LG.3A10, followed by a goat anti-hamster (Armenian) IgG antibody, Alexa Fluor® 488 (filled histogram), or an Armenian hamster IgG isotype control antibody, followed by a goat anti-hamster (Armenian) IgG antibody, Alexa Fluor® 488 (solid line histogram).
Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Anti-Mouse CD27 Antibody, Clone LG.3A10, PE (filled histogram) or an Armenian hamster IgG isotype control antibody, PE (solid line histogram).
