Anti-Human CD326 (EpCAM) Antibody, Clone VU-1D9_产品中心

抗体

Anti-Human CD326 (EpCAM) Antibody, Clone VU-1D9

Mouse monoclonal IgG1 antibody against human CD326 (EpCAM)

概要

技术资料

数据及文献

概要

The VU-1D9 antibody reacts with the human epithelial cell adhesion molecule (EpCAM or CD326), an ~40 kDa type I transmembrane glycoprotein, which functions as a homophilic and Ca++-independent adhesion molecule. Binding of the VU-1D9 antibody requires the presence of the extracellular EGF-1 domain of EpCAM. EpCAM has roles in several cellular processes, including signaling, migration, proliferation, and differentiation. It is expressed early during erythrogenesis and has been identified as a stem cell marker. The EpCAM protein is found on the basolateral membrane of most normal epithelial cells and is highly expressed in bone marrow, colon, and lung. EpCAM is not expressed on mesothelial cells or mesotheliomas, and so is widely used as a diagnostic marker to distinguish mesothelioma and carcinoma cells, as well as serving as a target for immunotherapeutic treatment of carcinomas. The VU-1D9 antibody has been used to identify and isolate circulating tumor cells.

技术资料

Document Type	产品名称	Catalog #	Lot #	语言
Product Information Sheet	Anti-Human CD326 (EpCAM) Antibody, Clone VU-1D9	60136	All	English
Product Information Sheet	Anti-Human CD326 (EpCAM) Antibody, Clone VU-1D9, FITC	60136FI	All	English
Safety Data Sheet 1	Anti-Human CD326 (EpCAM) Antibody, Clone VU-1D9	60136	All	English
Safety Data Sheet 2	Anti-Human CD326 (EpCAM) Antibody, Clone VU-1D9	60136	All	English
Safety Data Sheet	Anti-Human CD326 (EpCAM) Antibody, Clone VU-1D9, FITC	60136FI	All	English

数据及文献

Data

Figure 1. Data for Unconjugated

Flow cytometry analysis of human MCF7 cells labeled with Anti-Human CD326 (EpCAM) Antibody, Clone VU-1D9, followed by a rat anti-mouse IgG1 antibody, FITC (filled histogram) or a mouse IgG1, kappa isotype control antibody, followed by a rat anti-mouse IgG1 antibody, FITC (solid line histogram).

Figure 2. Data for FITC-conjugated

(A) Flow cytometry analysis of human embryonic stem (ES) cells labeled with Anti-Human CD326 (EpCAM) Antibody, Clone VU-1D9, FITC (filled histogram) or a mouse IgG1, kappa FITC isotype control antibody (solid line histogram).

(B) Flow cytometry analysis of human MCF7 cells labeled with Anti-Human CD326 (EpCAM) Antibody, Clone VU-1D9, FITC (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, FITC (Catalog #60070FI; solid line histogram).