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概要
The LNH-94 antibody reacts with human CD298, the β3 subunit of the Na+/K+ ATPase. The Na+/K+ ATPase is a 42 kDa type II transmembrane protein composed of four catalytic α subunits and three smaller glycosylated non-catalytic β subunits. The Na+/K+ ATPase is important for establishing electrochemical gradients and maintaining normal resting membrane potential by coupling ATP hydrolysis to the active transport of Na+ and K+. The β subunits have been reported to act as chaperones that stabilize the α subunits and occlude K+. CD298 has been used to identify metastatic human cancer cells in mouse xenograft models and has been reported to modulate aspects of immunity, including HIV production, and T cell and B cell activation. CD298 is found on leukocytes, platelets, and most other tissue types.
技术资料
| Document Type | 产品名称 | Catalog # | Lot # | 语言 |
|---|---|---|---|---|
| Product Information Sheet | Anti-Human CD298 Antibody, Clone LNH-94, APC | 60159AZ | All | English |
| Product Information Sheet | Anti-Human CD298 Antibody, Clone LNH-94, PE | 60159PE | All | English |
| Safety Data Sheet | Anti-Human CD298 Antibody, Clone LNH-94, APC | 60159AZ | All | English |
| Safety Data Sheet | Anti-Human CD298 Antibody, Clone LNH-94, PE | 60159PE | All | English |
数据及文献
Data
Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs; gated on lymphocytes) labeled with Anti-Human CD298 Antibody, Clone LNH-94, PE (filled histogram), or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, PE (Catalog #60070PE; solid line histogram).
Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs; gated on lymphocytes) labeled with Anti-Human CD298 Antibody, Clone LNH-94, APC (filled histogram), or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, APC (Catalog # 60070AZ; solid line histogram).
