Anti-Human CD51 Antibody, Clone NKI-M9_产品中心_北京砺达辰生物科技有限公司

概要

The NKI-M9 antibody reacts with CD51 (vitronectin receptor α chain, or integrin αV), a type I transmembrane glycoprotein containing two subunits (125 kDa and 24 kDa) which are generated by post-translational cleavage and are linked by a disulfide bond. CD51 associates non-covalently with integrin β1 (CD29), β3 (CD61), β5, β6, or β8 to form heterodimeric cell adhesion receptors for extracellular matrix components such as fibrinogen, collagen, fibronectin, laminin, osteopontin, thrombospondin, vitronectin, and von Willebrand factor. For example, association of CD51 and CD61 forms the integrin αv/β3 receptor primarily involved in binding vitronectin. In addition to mediating adhesion and cytoskeletal organization, CD51-containing integrins have roles in signal transduction and thereby modulate processes such as cell proliferation, differentiation, and migration. Both ligand binding and ligand-induced receptor clustering are necessary for initiating integrin-mediated responses. CD51 is expressed broadly on many types of cells, including endothelial cells, fibroblasts, monocytes, macrophages, platelets (at relatively low levels), and osteoclasts. It is also found on hepatoma, melanoma, and neuroblastoma cells.

技术资料

Document Type	产品名称	Catalog #	Lot #	语言
Product Information Sheet	Anti-Human CD51 Antibody, Clone NKI-M9	60043	All	English
Product Information Sheet	Anti-Human CD51 Antibody, Clone NKI-M9, Biotin	60043BT	All	English
Product Information Sheet	Anti-Human CD51 Antibody, Clone NKI-M9, FITC	60043FI, 60043FI.1	All	English
Product Information Sheet	Anti-Human CD51 Antibody, Clone NKI-M9, PE	60043PE, 60043PE.1	All	English
Safety Data Sheet	Anti-Human CD51 Antibody, Clone NKI-M9	60043	All	English
Safety Data Sheet	Anti-Human CD51 Antibody, Clone NKI-M9, Biotin	60043BT	All	English
Safety Data Sheet	Anti-Human CD51 Antibody, Clone NKI-M9, FITC	60043FI, 60043FI.1	All	English
Safety Data Sheet	Anti-Human CD51 Antibody, Clone NKI-M9, PE	60043PE, 60043PE.1	All	English

数据及文献

Data

Figure 1. Data for Unconjugated

Flow cytometry analysis of HT1080 human fibrosarcoma cells labeled with Anti-Human CD51 Antibody, Clone NKI-M9, followed by Goat Anti-Mouse IgG (H+L) Antibody, Polyclonal, FITC (Catalog #60138FI) (filled histogram), or Mouse IgG2a, kappa Isotype Control Antibody, Clone MOPC173 (Catalog #60071), followed by Goat Anti-Mouse IgG (H+L) Antibody, Polyclonal, FITC (solid line histogram).

Figure 2. Data for FITC-Conjugated

Flow cytometry analysis of human HT-1080 fibrosarcoma cells labeled with Anti-Human CD51 Antibody, Clone NKI-M9, FITC (filled historgram) or a mouse IgG2a, kappa FITC isotype control antibody (open histogram).

Figure 3. Data for PE-Conjugated

Flow cytometry analysis of human HT1080 fibrosarcoma cells labeled with Anti-Human CD51 Antibody, Clone NKI-M9, PE (filled histogram) or a mouse IgG2a, kappa PE isotype control antibody (solid line histogram).

Figure 4. Data for Biotin-Conjugated

Flow cytometry analysis of human HT1080 fibrosarcoma cells labeled with Anti-Human CD51 Antibody, Clone NKI-M9, Biotin, followed by streptavidin (SAV) APC (filled histogram), or Mouse IgG2a, kappa Isotype Control Antibody, Clone MOPC-173, Biotin (Catalog #60071BT), followed by SAV APC (solid line histogram).