Anti-Human CD41 Antibody, Clone HIP8_产品中心_北京砺达辰生物科技有限公司

概要

The HIP8 antibody reacts with the ~125 kDa GPIIbα subunit of human CD41, a heterodimeric integrin expressed primarily on platelets, megakaryocytes, monocytes, and acute megakaryoblastic leukemia cells. The GPIIbα subunit is linked to a smaller ~25 kDa subunit (GPIIbβ) by a single disulfide bond. Three isoforms of CD41 that are generated by alternative splicing have been identified, one of which is expressed only by cancerous cells. CD41 associates non-covalently with CD61 (integrin b3) in a calcium-dependent manner to form the CD41/CD61 (or GPIIb/IIIa) complex, which has been identified as a receptor for several ligands, including fibrinogen, fibronectin, vitronectin, and thrombin. Binding to the CD41/CD61 complex involves an RGD tripeptidyl sequence in the ligand, and both ligand occupancy and ligand-mediated receptor clustering are functionally important in the integrin-mediated response. The HIP8 antibody reportedly blocks platelet aggregation and inhibits the activation of platelets by several compounds.

技术资料

Document Type	产品名称	Catalog #	Lot #	语言
Product Information Sheet	Anti-Human CD41 Antibody, Clone HIP8	60114	All	English
Product Information Sheet	Anti-Human CD41 Antibody, Clone HIP8, APC	60114AZ, 60114AZ.1	All	English
Product Information Sheet	Anti-Human CD41 Antibody, Clone HIP8, FITC	60114FI, 60114FI.1	All	English
Product Information Sheet	Anti-Human CD41 Antibody, Clone HIP8, PE	60114PE, 60114PE.1	All	English
Safety Data Sheet	Anti-Human CD41 Antibody, Clone HIP8	60114	All	English
Safety Data Sheet	Anti-Human CD41 Antibody, Clone HIP8, APC	60114AZ, 60114AZ.1	All	English
Safety Data Sheet	Anti-Human CD41 Antibody, Clone HIP8, FITC	60114FI, 60114FI.1	All	English
Safety Data Sheet	Anti-Human CD41 Antibody, Clone HIP8, PE	60114PE, 60114PE.1	All	English

数据及文献

Data

Figure 1. Data for Unconjugated

Flow cytometry analysis of human platelets labeled with Anti-Human CD41 Antibody, Clone HIP8, followed by a rat anti-mouse IgG1 antibody, PE (filled histogram), or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21 (Catalog #60070), followed by a rat anti-mouse IgG1 antibody, PE (solid line histogram).

Figure 2. Data for APC-Conjugated

Flow cytometry analysis of human platelets labeled with Anti-Human CD41 Antibody, Clone HIP8, APC (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, APC (Catalog #60070AZ, solid line histogram).

Figure 3. Data for FITC-Conjugated

Flow cytometry analysis of human platelets labeled with Anti-Human CD41 Antibody, Clone HIP8, FITC (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, FITC (Catalog #60070FI, solid line histogram).

Figure 4. Data for PE-Conjugated

Flow cytometry analysis of human platelets labeled with Anti-Human CD41 Antibody, Clone HIP8, PE (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, PE (Catalog #60070PE, solid line histogram).