Anti-Human CD40 Antibody, Clone 5C3_产品中心_北京砺达辰生物科技有限公司

概要

The 5C3 antibody reacts with CD40, a 45 - 50 kDa type I transmembrane glycoprotein that is a member of the tumor necrosis factor receptor (TNFR) superfamily. CD40 plays an important role in B cell development and is also involved in the process of B cell selection in germinal centers. It facilitates T cell-B cell interactions for co-stimulation and immune regulation through engagement with CD154 (gp39), the CD40 ligand expressed on T cells. In the presence of IL-4, or other stimuli, CD40 promotes B cell proliferation, induces immunoglobulin- (Ig) isotype class switching and rescues B cells from surface Ig-induced apoptosis. CD40 is expressed on the surface of B cells, follicular dendritic cells, macrophages, fibroblasts, keratinocytes, endothelial cells, basal epithelial cells, CD34+ hematopoietic progenitor cells, and primary carcinomas. It is expressed at low levels, or not at all, on plasma cells. The 5C3 antibody has been used for the activation of B cells in in vitro functional assays or for the induction of B cell proliferation.

技术资料

Document Type	产品名称	Catalog #	Lot #	语言
Product Information Sheet	Anti-Human CD40 Antibody, Clone 5C3	60113	All	English
Product Information Sheet	Anti-Human CD40 Antibody, Clone 5C3, Alexa Fluor® 488	60113AD	All	English
Product Information Sheet	Anti-Human CD40 Antibody, Clone 5C3, APC	60113AZ, 60113AZ.1	All	English
Product Information Sheet	Anti-Human CD40 Antibody, Clone 5C3, FITC	60113FI, 60113FI.1	All	English
Product Information Sheet	Anti-Human CD40 Antibody, Clone 5C3, PE	60113PE, 60113PE.1	All	English
Safety Data Sheet	Anti-Human CD40 Antibody, Clone 5C3	60113	All	English
Safety Data Sheet	Anti-Human CD40 Antibody, Clone 5C3, Alexa Fluor® 488	60113AD	All	English
Safety Data Sheet	Anti-Human CD40 Antibody, Clone 5C3, APC	60113AZ, 60113AZ.1	All	English
Safety Data Sheet	Anti-Human CD40 Antibody, Clone 5C3, FITC	60113FI, 60113FI.1	All	English
Safety Data Sheet	Anti-Human CD40 Antibody, Clone 5C3, PE	60113PE, 60113PE.1	All	English

数据及文献

Data

Figure 1. Data for Unconjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs, gated on lymphocytes) labeled with Anti-Human CD40 Antibody, Clone 5C3, followed by a rat anti-mouse IgG1 antibody, PE (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21 (Catalog #60070), followed by a rat anti-mouse IgG1 antibody, PE (solid line histogram).

Figure 2. Data for Alexa Fluor® 488-Conjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs, gated on lymphocytes) labeled with Anti-Human CD40 Antibody, Clone 5C3, Alexa Fluor® 488 (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, Alexa Fluor® 488 (Catalog #60070AD, solid line histogram).

Figure 3. Data for APC-Conjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs, gated on lymphocytes) labeled with Anti-Human CD40 Antibody, Clone 5C3, APC (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, APC (Catalog #60070AZ, solid line histogram).

Figure 4. Data for FITC-Conjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs, gated on lymphocytes) labeled with Anti-Human CD40 Antibody, Clone 5C3, FITC (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, FITC (Catalog #60070FI, solid line histogram).

Figure 5. Data for PE-Conjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs, gated on lymphocytes) labeled with Anti-Human CD40 Antibody, Clone 5C3, PE (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, PE (Catalog #60070PE, solid line histogram).