Anti-Human CD36 Antibody, Clone FA6-152_产品中心_北京砺达辰生物科技有限公司

概要

The FA6-152 antibody reacts with CD36, an ~88 kDa transmembrane glycoprotein that functions as a scavenger receptor, cell adhesion molecule, and signal transducer on the surface of many types of cells including platelets, monocytes, macrophages, erythrocyte precursors, endothelial and epithelial cells, and some macrophage-derived dendritic cells. The topology of the protein is thought to comprise a large extracellular loop with the N- and C-termini both inserted through the cell membrane. CD36 binds multiple ligands such as thrombospondin, collagen, lipoproteins, and long-chain fatty acids, and has evident roles in the phagocytotic clearance of apoptotic cells, inhibition of angiogenesis, metabolism of glucose and fatty acids, inflammation, and the pathogenesis of malaria. Binding of the FA6-152 antibody to CD36 reportedly blocks its interaction with thrombospondin, collagen, apoptotic cells, and modified LDL, and induces agglutination of fetal but not adult erythrocytes. The epitope for FA6-152 reportedly resides within an immunodominant domain of CD36 comprising amino acids 155 - 183.

技术资料

Document Type	产品名称	Catalog #	Lot #	语言
Product Information Sheet	Anti-Human CD36 Antibody, Clone FA6-152	60084	All	English
Product Information Sheet	Anti-Human CD36 Antibody, Clone FA6-152, FITC	60084FI	All	English
Safety Data Sheet	Anti-Human CD36 Antibody, Clone FA6-152	60084	All	English
Safety Data Sheet	Anti-Human CD36 Antibody, Clone FA6-152, FITC	60084FI	All	English

数据及文献

Data

Figure 1. Data for Unconjugated

(A) Flow cytometry analysis of human erythroleukemia (HEL) cells labeled with Anti-Human CD36 Antibody, Clone FA6-152, followed by Goat Anti-Mouse IgG (H+L) Antibody, Polyclonal, FITC (Catalog #60138FI) (filled histogram), or a mouse IgG1, kappa isotype control antibody, followed by Goat Anti-Mouse IgG (H+L) Antibody, Polyclonal, FITC (solid line histogram). (B) Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD36 Antibody, Clone FA6-152, followed by Goat Anti-Mouse IgG (H+L) Antibody, Polyclonal, FITC (filled histogram), or a mouse IgG1, kappa isotype control antibody, followed by Goat Anti-Mouse IgG (H+L) Antibody, Polyclonal, FITC (solid line histogram).

Figure 2. Data for FITC-Conjugated

(A) Flow cytometry analysis of human erythroleukemia (HEL) cells labeled with Anti-Human CD36 Antibody, Clone FA6-152, FITC (filled histogram) or a mouse IgG1, kappa FITC isotype control antibody (solid line histogram). (B) Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD36 Antibody, Clone FA6-152, FITC (filled histogram) or a mouse IgG1, kappa FITC isotype control antibody (solid line histogram). (C) Flow cytometry analysis of human PBMCs processed with the EasySep™ Human CD14 Positive Selection Kit and labeled with Anti-Human CD36 Antibody, Clone FA6-152, FITC. Histograms show labeling of PBMCs (Start) and isolated cells (Isolated). Labeling of start cells with a mouse IgG1, kappa FITC isotype control antibody is shown (solid line histogram).