Anti-Human CD24 Antibody, Clone 32D12_产品中心_北京砺达辰生物科技有限公司

概要

The 32D12 antibody reacts with CD24, a 35 - 50 kDa glycosylphosphatidylinositol (GPI)-linked sialoglycoprotein that is anchored to the plasma membrane and is glycosylated variably depending on cell type. The function of CD24 has yet to be fully determined but it is believed to play a role in lymphocyte development, particularly in acting as a costimulatory molecule for CD4+ T cells and in regulating B cell proliferation, activation, differentiation, and apoptosis. CD24 may also function in cell adhesion and metastasis, likely through binding of CD62P (P-Selectin). CD24 is expressed by follicular dendritic cells, and various epithelial and hematopoietic cell types, including granulocytes, erythrocytes, most B cells, and subsets of T lymphocytes. As it is expressed throughout B cell development but is lost after differentiation into the plasma cell stage, CD24 may be used as a B cell differentiation marker. Furthermore, CD24 also has the potential to be a marker for tumor prognosis and diagnosis as it is highly expressed in numerous cancers including ovarian, breast, prostate, bladder, renal, and lung, as well as neuroblastomas and various hematological malignancies. Reportedly, the 32D12 antibody recognizes an epitope that is distinct from those recognized by clones VIB-C5, VIB-E3, LC66, BA-1, ML5, OKB2 and SN3 A5-2H10.

技术资料

Document Type	产品名称	Catalog #	Lot #	语言
Product Information Sheet	Anti-Human CD24 Antibody, Clone 32D12	60134	All	English
Product Information Sheet	Anti-Human CD24 Antibody, Clone 32D12, Biotin	60134BT	All	English
Product Information Sheet	Anti-Human CD24 Antibody, Clone 32D12, FITC	60134FI	All	English
Safety Data Sheet 1	Anti-Human CD24 Antibody, Clone 32D12	60134	All	English
Safety Data Sheet 2	Anti-Human CD24 Antibody, Clone 32D12	60134	All	English
Safety Data Sheet	Anti-Human CD24 Antibody, Clone 32D12, Biotin	60134BT	All	English
Safety Data Sheet	Anti-Human CD24 Antibody, Clone 32D12, FITC	60134FI	All	English

数据及文献

Data

Figure 1. Data for Unconjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs; gated on lymphocytes) labeled with Anti-Human CD24 Antibody, Clone 32D12 followed by a rat anti-mouse IgG1 antibody, FITC (filled histogram), or a mouse IgG1, kappa isotype control antibody followed by a rat anti-mouse IgG1 antibody, FITC (solid line histogram).

Figure 2. Data for Biotin-conjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs; gated on lymphocytes) labeled with Anti-Human CD24 Antibody, Clone 32D12, Biotin followed by streptavidin (SAV) FITC (filled histogram), or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, Biotin (Catalog #60070BT) followed by SAV FITC (solid line histogram).

Figure 3. Data for FITC-conjugated

Flow cytometry analysis of human perifpheral blood mononuclear cells (PBMCs; gated on lymphocytes) labeled with Anti-Human CD24 Antibody, Clone 32D12, FITC (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, FITC (Catalog #60070FI; solid line histogram).