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Anti-Human CD3 Antibody, Clone SK7

Mouse monoclonal IgG1 antibody against human, chimpanzee CD3

概要
技术资料
数据及文献

概要

The SK7 antibody reacts with the ~20 kDa CD3ε subunit of the human T cell receptor (TCR)/CD3 complex, which is expressed on the surface of ~95% of mature T cells and NKT cells, and variably on thymocytes. A majority of T cell neoplasms also express CD3. The CD3 complex, which is assembled from combinations of CD3γ, δ, ε, η and ζ subunits, associates non-covalently with the TCR and is involved in transducing antigen recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR. Activation of T cells by the TCR involves the cytoplasmic tails of the CD3 subunits, which are structurally related type 1 transmembrane proteins and members of the immunoglobulin superfamily. Mutations in the CD3 subunits have been associated with various immunodeficiency disorders, including severe combined immunodeficiency (SCID).

技术资料

Document Type 产品名称 Catalog # Lot # 语言
Product Information Sheet Anti-Human CD3 Antibody, Clone SK7, FITC 60127FI, 60127FI.1 All English
Safety Data Sheet Anti-Human CD3 Antibody, Clone SK7, FITC 60127FI, 60127FI.1 All English

数据及文献

Data

Figure 1. Data for FITC Conjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD3 Antibody, Clone SK7, FITC (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, FITC (Catalog #60070FI; solid line histogram).