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概要
The TUJ1 antibody reacts with beta-tubulin III, an ~50 - 55 kDa structural protein that is a component of tubulin. Tubulin is the major component of microtubules within the cytoskeleton and is assembled from heterodimers of alpha and beta tubulin subunits. The beta III isoform of tubulin, also known as neuron-specific class III beta-tubulin, is expressed primarily in neurons and is widely used as a marker to distinguish neurons from other cell types. Beta-tubulin III contributes to microtubule formation in neuronal cell bodies and axons, a function involving GTP binding, and plays roles in axonal transport, neuronal cell proliferation, and differentiation. It is highly expressed in several types of cancer and is a predictive and prognostic marker for various tumors, for example, being found in neoplastic but not in normal glial cells. The TUJ1 antibody is expected to recognize all mammalian homologs of beta-tubulin III and the epitope has reportedly been mapped to the C-terminal 15 amino acids of the protein.
技术资料
| Document Type | 产品名称 | Catalog # | Lot # | 语言 |
|---|---|---|---|---|
| Product Information Sheet | Anti-Beta-Tubulin III Antibody, Clone TUJ1 | 60052 | All | English |
| Safety Data Sheet | Anti-Beta-Tubulin III Antibody, Clone TUJ1 | 60052 | All | English |
数据及文献
Data
E18 cortical rat neurons were cultured using NeuroCult™ SM1 Neuronal Culture Kit on poly-L-ornithine and laminin-coated glass coverslips, then fixed and labeled with Anti-Beta-Tubulin III Antibody, Clone TUJ1, followed by donkey anti-mouse IgG, Alexa Fluor® 488, and counterstained with DAPI.
