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概要
SH2-containing inositol phosphatase (SHIP) is a 145 kDa hematopoietic-restricted protein that becomes tyrosine-phosphorylated and associated with the adaptor protein, Shc, following cytokine, growth factor, chemokine, and immunoreceptor stimulation. SHIP also hydrolyzes the critical phosphatidylinositol (PI)-3-kinase (PI3K)-generated second messenger, PI-3,4,5-P3 (PIP3), to PI-3,4-P2 1,2 and therefore acts as an important negative regulator of the PI3K pathway. This antibody reacts with mouse full-length SHIP protein, 145 kDa, as well as the C-terminal truncated 135, 125, and 110 kDa forms.
技术资料
| Document Type | 产品名称 | Catalog # | Lot # | 语言 |
|---|---|---|---|---|
| Product Information Sheet | Anti-SHIP Antibody, Polyclonal | 60141 | All | English |
| Safety Data Sheet | Anti-SHIP Antibody, Polyclonal | 60141 | All | English |
数据及文献
Data
Western blot analysis of mouse bone marrow derived mast cells (BMMCs) from normal (+/+) and SHIP knockout (-/-) mice with Anti-SHIP Antibody, Polyclonal (1:4000 dilution). SHIP has a predicted molecular mass of 145 kDa.
