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概要
SHIP2 is a 145 kDa SHIP-related protein expressed in both hematopoietic and nonhematopoietic cells. Like SH2-containing inositol phosphatase (SHIP), SHIP2 becomes tyrosine phosphorylated and associated with the adaptor protein, Shc, following cytokine, growth factor, chemokine, and immunoreceptor stimulation. SHIP2 also hydrolyzes the critical phosphatidylinositol (PI)-3-kinase (PI3K)-generated second messenger, PI-3,4,5-P3 (PIP3), to PI-3,4-P2 1,2 and therefore acts as an important negative regulator of the PI3K pathway. This antibody reacts with mouse and human full-length 145 kDa SHIP2 protein.
技术资料
| Document Type | 产品名称 | Catalog # | Lot # | 语言 |
|---|---|---|---|---|
| Product Information Sheet | Anti-SHIP2 Antibody, Polyclonal | 60143 | All | English |
| Safety Data Sheet | Anti-SHIP2 Antibody, Polyclonal | 60143 | All | English |
数据及文献
Data
Western blot analysis of total cell lysates (TCL) from human TF-1 cells, mouse WEHI-231 B cells, and mouse bone marrow derived mast cells (BMMCs) of SHIP +/+ and SHIP -/- mice with Anti-SHIP2 Antibody, Polyclonal (1:1000 dilution). The last two lanes represent anti-SHIP2 immunoprecipitates (IP) of 1 x 107 TF-1 cells and WEHI-231 B cells, respectively. SHIP2 has a predicted molecular mass of 145 kDa.
