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概要
SHIP (C-terminus) is critical for the function of SHIP protein. SH2-containing inositol phosphatase (SHIP) is a 145 kDa hematopoietic-restricted protein that becomes tyrosine-phosphorylated and associated with the adaptor protein, Shc, following cytokine, growth factor, chemokine, and immunoreceptor stimulation. SHIP also hydrolyzes the critical phosphatidylinositol (PI)-3-kinase (PI3K)-generated second messenger, PI-3,4,5-P3 (PIP3), to PI-3,4-P2 1,2 and therefore acts as an important negative regulator of the PI3K pathway. This antibody reacts with mouse and human full-length 145 kDa SHIP protein.
技术资料
| Document Type | 产品名称 | Catalog # | Lot # | 语言 |
|---|---|---|---|---|
| Product Information Sheet | Anti-SHIP (C-Terminus) Antibody, Polyclonal | 60144 | All | English |
| Safety Data Sheet | Anti-SHIP (C-Terminus) Antibody, Polyclonal | 60144 | All | English |
数据及文献
Data
Western blot analysis of total cell lysates from human TF-1 cells (lane 1), mouse WEHI-231 cells (lane 2) and mouse bone marrow derived mast cells (BMMCs; lane 3) with Anti-SHIP (C-Terminus) Antibody, Polyclonal (1:1000 dilution). SHIP has a predicted molecular mass of 145 kDa.
